Arizona Tribune - Form Bio and Weill Cornell Medicine Announces Strategic Collaboration to Advance Gene Editing Therapy for Alzheimer's Disease

AUSTIN, TX AND NEW YORK, NY / ACCESS Newswire / October 30, 2025 / Form Bio, a leader in AI-powered genetic medicine development and genome engineering, today announced a collaborative research agreement with Weill Cornell Medicine applying gene editing to develop drugs that reduce Alzheimer's disease risk in patients carrying high-risk genetic variants.

This multi-phase initiative represents a significant step toward addressing one of the strongest genetic drivers of Alzheimer's disease. Today, more than 7 million Americans over the age of 65 are living with Alzheimer's, and over 55 million people globally are affected by dementia, according to the World Health Organization. That number is projected to triple by 2050. Carriers of the APOE4 allele face a substantially higher likelihood of developing Alzheimer's, making it a critical target for intervention.

"Our early data has shown efficient AAV-mediated prime editing of the high risk APOE4 allele to the low risk APOE3 variant in a preclinical animal model of Alzheimer's disease. This research collaboration has the potential to accelerate the optimization of these vector cassettes and increase the likelihood of developing a safe and effective therapy for future clinical studies in patients with Alzheimer's disease," said Dolan Sondhi, PhD, Principal Investigator of the project and Professor of Research in Genetic Medicine at Weill Cornell Medicine.

"The combination of Weill Cornell's cutting-edge gene editing expertise and deep understanding of neurodegenerative disease biology with Form Bio's AI-driven vector design platform gives us a unique opportunity to explore one of the greatest unmet needs in medicine," said Michelle Chen, PhD, President and Chief Executive Officer at Form Bio. "By focusing on genetically defined high-risk patients, we're laying the groundwork for a potentially transformative approach to Alzheimer's disease."

Dr. Dolan Sondhi serves as an advisory board member for Form Bio, Inc.

About Form Bio
Form Bio is a leader in developing AI-powered solutions for genetic medicine and genome engineering. Since spinning out from Colossal Biosciences in 2022, the company has become a trusted innovation partner to cell and gene therapy developers and beyond. Form Bio's advanced in silico technology and computational platforms deliver deep insights into genome integrity, optimized payload design, and other critical factors-enabling safer, more efficacious, and more manufacturable therapeutics. By reducing risk, shortening timelines, and optimizing outcomes, Form Bio helps drug developers accelerate the path from discovery to the clinic. For more information, visit www.formbio.com or follow us on LinkedIn.

Contact Information
Angela Anderson
Form Bio
[email protected]

SOURCE: Form Bio

View the original press release on ACCESS Newswire

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